Ccd
Radiation induced Allele Detail

Summary

• Symbol: Ccd
• Name: cleidocranial dysplasia
• MGI ID: MGI:1861187
• Synonyms: 320
• Gene: Ccd Location: unknown Genetic Position: Chr17, Syntenic
• Alliance: Ccd page

Mutation origin

• Strain of Origin: 101

Mutation description

• Allele Type: Radiation induced
• Mutation: Intergenic deletion
• Mutation details: Genetic analysis of Ccd mice showed a 2 cM deletion on chromosome 17 in an area of synteny to human 6p. The deletion is flanked on one side by the Tcte1 gene, involves Runx1, but extends further proximally, also deleting Mut. (J:40784)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccd Mutation: 0 strains or lines available

Notes

Induced by gamma irradiation in a 101 strain male. Heterozygotes show striking homology to cleidocranial dysplasia, a skeletal disorder in man. The mutation is fully penetrant in heterozygotes. It causes partial or complete failure of ossification of clavicles, symphysis pubis, and cranial fontanelles. This mutation is lethal in homozygotes (J:14006).

References

• Original: J:14006 Selby P, et al., Cleidocranial dysplasia, Ccd. Mouse News Lett. 1985;72:123
• All: 6 reference(s)