Tbx10^Dc
Spontaneous Allele Detail

Summary

• Symbol: Tbx10^Dc
• Name: T-box 10; dancer
• MGI ID: MGI:1861236
• Synonyms: Dc
• Gene: Tbx10 Location: Chr19:4042752-4049512 bp, + strand Genetic Position: Chr19, 3.71 cM, cytoband A
• Alliance: Tbx10^Dc page

Mutation origin

• Strain of Origin: C3.Cg-Lep^ob

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: The mutation in this allele comprises a small translocation insertion that placed a 3.3 kb fragment of Chr 10 into intron 1 of the Tbx10 gene. This inserted sequence includes exon 1 of the Tebp gene. RT-PCR analysis of Tbx10 expression revealed that the full-length trancript is expressed normally in mutant mice, and that a chimeric transcript consisting of the Tebp exon 1 of the inserted sequence fused in-frame to exon 2 of the Tbx10 gene is expressed ectopically. This chimeric transcript is predicted to encode a trucated, but functional protein that is similar to a normal variant. (J:89946)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx10 Mutation: 16 strains or lines available

References

• Original: J:24773 Lane PW, New mutants: Dancer, Athetoid, and mahogany. Mouse News Lett. 1958;19:25
• All: 12 reference(s)