Lse
Spontaneous Allele Detail

Summary

• Symbol: Lse
• Name: low set ears
• MGI ID: MGI:1861623
• Gene: Lse Location: unknown Genetic Position: Chr7, Syntenic

Mutation origin

• Strain of Origin: STOCK Lmx1a^dr-J x C3HeB/FeJLe-a/a

Mutation description

• Allele Type: Spontaneous
• Mutations: Duplication, Insertion
• Lse involves 8 genes/genome features (Ano1, D930030F02Rik, Gm44930 ...) View all
• Mutation details: A 148 kb region (Chr7:144,718,321144,866,450; GRCm38/mm10) including full copies of Fgf3 and Fgf4 and the first exon of Ano1 is present as a tandem duplication along with a 5bp insertion (TATAT). Ectopic expression of Fgf3 is seen in the second branchial arch in hE10.5 heterozygous embryos and in the developing urogenital ridge and adjacent to the forelimb bud of E10.5 homozygous embryos. Ectopic expression of Fgf4 is seen in paired domains close to the ventral midline adjacent to the third and fourth aches in E9.5 heterozygous and homozygous embryos. (J:338204)
• Inheritance: Dominant

Disease models

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lse Mutation: 1 strain or line available

References

• Original: J:8618 Theiler K, et al., Low set ears (Lse), a new mutation of the house mouse. Anat Embryol (Berl). 1986;175(2):241-6
• All: 3 reference(s)