Fancl^gcd
Transgenic Allele Detail

Summary

• Symbol: Fancl^gcd
• Name: Fanconi anemia, complementation group L; germ cell deficient
• MGI ID: MGI:1861640
• Synonyms: gcd, Phf9^gcd
• Gene: Fancl Location: Chr11:26337084-26421883 bp, + strand Genetic Position: Chr11, 15.85 cM, cytoband A2-A3
• Alliance: Fancl^gcd page

Histological sections of adult Fancl^gcd/Fancl^gcd mouse gonads

Show the 3 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (CBA/J x C57BL/6J)F2

Transgene description

• Transgene Type: Transgenic
• Mutations: Insertion, Intergenic deletion
• Mutation details: This mutation was identified as a transgene insertion that also deletes approximately 150 kb of genomic sequence at the insertion site. This deletion removes exons 4-14 of Fancl and also removes exons 2-11 of a neighboring gene Vrk2. The transgene contains a fragment of goat DNA. A transgene expressing Vrk2 that was introduced into homozygous mice failed to rescue the phenotype, suggesting that the deletion of Fancl was solely responsible for the phenotype seen in these mice. (J:80424)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fancl Mutation: 29 strains or lines available

References

• Original: J:21254 Pellas TC, et al., Germ-cell deficient (gcd), an insertional mutation manifested as infertility in transgenic mice. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8787-91
• All: 5 reference(s)