Itgb2^tm2Bay
Targeted Allele Detail

Summary

• Symbol: Itgb2^tm2Bay
• Name: integrin beta 2; targeted mutation 2, Baylor College of Medicine
• MGI ID: MGI:1861705
• Synonyms: beta2^-, CD18-, CD18 null, Itgb2-
• Gene: Itgb2 Location: Chr10:77366164-77401542 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Itgb2^tm2Bay page

Skeletal abnormalities in Itgb2^tm2Bay/Itgb2^tm2Bay mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:13599
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette disrupted the 5' boundary of exon 3. No protein was synthesized from this allele. (J:48542)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Itgb2 Mutation: 50 strains or lines available

References

• Original: J:13599 Wilson RW, et al., Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol. 1993 Aug 1;151(3):1571-8
• All: 121 reference(s)