Was^tm1Sbs
Targeted Allele Detail

Summary

• Symbol: Was^tm1Sbs
• Name: Wiskott-Aldrich syndrome; targeted mutation 1, Scott B Snapper
• MGI ID: MGI:1861707
• Synonyms: Was^-, wasp-
• Gene: Was Location: ChrX:7947705-7956730 bp, - strand Genetic Position: ChrX, 3.65 cM
• Alliance: Was^tm1Sbs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48836
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 7, which encodes part of the GTPase-binding domain. The absence of transcript and protein produced from the targeted allele in male hemizygous mutant mice was confirmed by Northern blot and Western blot analyses. (J:48836)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Was Mutation: 12 strains or lines available

References

• Original: J:48836 Snapper SB, et al., Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity. 1998 Jul;9(1):81-91
• All: 85 reference(s)