Vamp8^{Gt(OST20346)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Vamp8^{Gt(OST20346)Lex}
• Name: vesicle-associated membrane protein 8; gene trap OST20346, Lexicon Genetics
• MGI ID: MGI:1861709
• Synonyms: Vamp-8^-, Vamp8^{Gt(VICTR20)17Lex}, Vamp8^tm1Lex
• Gene: Vamp8 Location: Chr6:72362204-72367650 bp, - strand Genetic Position: Chr6, 32.27 cM
• Alliance: Vamp8^{Gt(OST20346)Lex} page

Mutation origin

• Mutant Cell Line: OST20346
• Germline Transmission: Earliest citation of germline transmission: J:131926
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: A genetrap vector inserted in the proximity of exon 3. mRNA is not detected by northern blot in homozygote-null heart and muscle; mRNA is barely detected by northern blot in homozygote kidney. Aberrant transcripts are detected in heterozygote and homozygote kidney. (J:131926)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST20346	CG485756 ; (MGI Seq Detail)	3' RACE	Chr6:72362322-72362581 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  13 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vamp8 Mutation: 19 strains or lines available

References

• Original: J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
• All: 4 reference(s)