Trp63^tm1Brd
Targeted Allele Detail

Summary

• Symbol: Trp63^tm1Brd
• Name: transformation related protein 63; targeted mutation 1, Allan Bradley
• MGI ID: MGI:1861713
• Synonyms: p63^Brdm1
• Gene: Trp63 Location: Chr16:25502513-25710842 bp, + strand Genetic Position: Chr16, 17.37 cM
• Alliance: Trp63^tm1Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54636
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An integration vector disrupts the reading frame within exon 6. Northern blot analysis on homozygous mutant animals indicates that an mRNA transcript is not produced from this allele. (J:54636)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp63 Mutation: 60 strains or lines available

References

• Original: J:54636 Mills AA, et al., p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature. 1999 Apr 22;398(6729):708-13
• All: 13 reference(s)