Gjc1^tm1.1Kni
Targeted Allele Detail

Summary

• Symbol: Gjc1^tm1.1Kni
• Name: gap junction protein, gamma 1; targeted mutation 1.1, Kiyomasa Nishii
• MGI ID: MGI:1861741
• Synonyms: Cx45-, delta45nlacZ, nls-lacZ
• Gene: Gjc1 Location: Chr11:102690405-102710526 bp, - strand Genetic Position: Chr11, 66.48 cM
• Alliance: Gjc1^tm1.1Kni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63214
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region of the gene, which is a single exon, was deleted and replaced by a construct containing the sequences for a lacZ gene and a loxP-flanked PGK-neomycin resistance gene cassette. This allele, Gja7^tm1.1Kni, was derived when cre was expressed, resulting in the removal of the neomycin resistance gene. (J:63214)

Expression

In Mice Carrying this Mutation:	50 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gjc1 Mutation: 33 strains or lines available

References

• Original: J:63214 Kumai M, et al., Loss of connexin45 causes a cushion defect in early cardiogenesis. Development. 2000 Aug;127(16):3501-12
• All: 3 reference(s)