Pak2^{Gt(OST104058)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Pak2^{Gt(OST104058)Lex}
• Name: p21 (RAC1) activated kinase 2; gene trap OST104058, Lexicon Genetics
• MGI ID: MGI:1861800
• Gene: Pak2 Location: Chr16:31835108-31898160 bp, - strand Genetic Position: Chr16, 22.4 cM
• Alliance: Pak2^{Gt(OST104058)Lex} page

Mutation origin

• Mutant Cell Line: OST104058
• Germline Transmission: Earliest citation of germline transmission: J:46940
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap cassette consisting of an long terminal repeat (LTR), splice acceptor sequence (SA), internal ribosome entry site-galactosidase/neomycin phosphotransferase fusion gene (IRES-geo), polyadenylation sequence, phosphoglycerate kinase-1 promoter (PGK), puromycin N-acetyltransferase gene, splice donor sequence (SD), and LTR, inserted before exon 2. Western blot analysis indicates that levels of protein in the hippocampus and cortex are reduced in heterozygotes. (J:271067)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST104058	CG526865 ; (MGI Seq Detail)	3' RACE	Chr16:31870992-31871115 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  54 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pak2 Mutation: 66 strains or lines available

References

• Original: J:46940 Zambrowicz BP, et al., Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature. 1998 Apr 9;392(6676):608-11
• All: 3 reference(s)