Cd38^tm1Lnd
Targeted Allele Detail

Summary

• Symbol: Cd38^tm1Lnd
• Name: CD38 antigen; targeted mutation 1, Frances E Lund
• MGI ID: MGI:1861803
• Synonyms: CD38-, CD38^null, Cd38^tm1Lud
• Gene: Cd38 Location: Chr5:44026153-44069714 bp, + strand Genetic Position: Chr5, 23.85 cM
• Alliance: Cd38^tm1Lnd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49170
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 2 and 3, which encode the putative active site of the encoded protein. Homozygous mice lacked transcripts derived from this allele (data not shown). Flow cytometry analysis on splenocytes derived from homozygous mice confirmed that no detectable protein was expressed on the cell surface. (J:49170)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Cd38 Mutation: 53 strains or lines available

References

• Original: J:49170 Cockayne DA, et al., Mice deficient for the ecto-nicotinamide adenine dinucleotide. Blood. 1998 Aug 15;92(4):1324-33
• All: 90 reference(s)