Cdh6^tm1Sma
Targeted Allele Detail

Summary

• Symbol: Cdh6^tm1Sma
• Name: cadherin 6; targeted mutation 1, Steven P Mah
• MGI ID: MGI:1861807
• Synonyms: Cad-6 -
• Gene: Cdh6 Location: Chr15:13028787-13173761 bp, - strand Genetic Position: Chr15, 6.11 cM
• Alliance: Cdh6^tm1Sma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63195
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 1 at codon 68. Western blot analysis on embryonic kidney lysates derived from homozygous mice demonstrated that no detectable protein was produced from this allele. Immunohistochemistry expermients confirmed that homozygous mice did not express detectable levels of the encoded protein (data not shown). (J:63195)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh6 Mutation: 40 strains or lines available

References

• Original: J:63195 Mah SP, et al., Kidney development in cadherin-6 mutants: delayed mesenchyme-to-epithelial conversion and loss of nephrons. Dev Biol. 2000 Jul 1;223(1):38-53
• All: 4 reference(s)