Cdk5^tm1Kul
Targeted Allele Detail

Summary

• Symbol: Cdk5^tm1Kul
• Name: cyclin dependent kinase 5; targeted mutation 1, Ashok B Kulkarni
• MGI ID: MGI:1861809
• Synonyms: Cdk5 (-)
• Gene: Cdk5 Location: Chr5:24623239-24628528 bp, - strand Genetic Position: Chr5, 11.73 cM, cytoband A3-B1
• Alliance: Cdk5^tm1Kul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64289
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of part of exon III, exons IV and V with a neomycin cassette. (J:64289)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	52 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cdk5 Mutation: 17 strains or lines available

References

• Original: J:64289 Ohshima T, et al., Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11173-8
• All: 59 reference(s)