Cnga2^tm1Ngai
Targeted Allele Detail

Summary

• Symbol: Cnga2^tm1Ngai
• Name: cyclic nucleotide gated channel alpha 2; targeted mutation 1, John Ngai
• MGI ID: MGI:1861912
• Synonyms: CNG channel alpha -
• Gene: Cnga2 Location: ChrX:71035455-71053824 bp, + strand Genetic Position: ChrX, 37.15 cM, cytoband A6
• Alliance: Cnga2^tm1Ngai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36286
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment containing the sequences encoding the fifth membrane-spanning region, the pore-forming region, the sixth membrane-spanning region and a portion of the carboxy-terminal tail. (J:36286, J:96894)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cnga2 Mutation: 17 strains or lines available

References

• Original: J:36286 Brunet LJ, et al., General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron. 1996 Oct;17(4):681-93
• All: 15 reference(s)