Csk^tm1Sor
Targeted Allele Detail

Summary

• Symbol: Csk^tm1Sor
• Name: c-src tyrosine kinase; targeted mutation 1, Philippe Soriano
• MGI ID: MGI:1861914
• Synonyms: Csk-
• Gene: Csk Location: Chr9:57533929-57560758 bp, - strand Genetic Position: Chr9, 31.18 cM
• Alliance: Csk^tm1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:12622
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Deletion of all coding sequences and replacement with a neomycin cassette. (J:12622)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Csk Mutation: 27 strains or lines available

References

• Original: J:12622 Imamoto A, et al., Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Cell. 1993 Jun 18;73(6):1117-24
• All: 9 reference(s)