Cux1^tm1Ejn
Targeted Allele Detail

Summary

• Symbol: Cux1^tm1Ejn
• Name: cut-like homeobox 1; targeted mutation 1, Ellis J Neufeld
• MGI ID: MGI:1861916
• Synonyms: deltaCR1
• Gene: Cux1 Location: Chr5:136276989-136596344 bp, - strand Genetic Position: Chr5, 75.96 cM
• Alliance: Cux1^tm1Ejn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49157
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exons 10 and 11. Western blot analysis on spleen and thymus extracts of homozygous mice demonstrated that a mutant protein that lacked cut domain 1, but retains DNA binding activity, was produced from this allele. (J:49157)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cux1 Mutation: 112 strains or lines available

References

• Original: J:49157 Tufarelli C, et al., Hair defects and pup loss in mice with targeted deletion of the first cut repeat domain of the Cux/CDP homeoprotein gene. Dev Biol. 1998 Aug 1;200(1):69-81
• All: 4 reference(s)