Epor^tm1Lizon
Targeted Allele Detail

Summary

• Symbol: Epor^tm1Lizon
• Name: erythropoietin receptor; targeted mutation 1, Leonard I Zon
• MGI ID: MGI:1861922
• Synonyms: EpoR-
• Gene: Epor Location: Chr9:21870193-21874802 bp, - strand Genetic Position: Chr9, 7.93 cM
• Alliance: Epor^tm1Lizon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35594
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing the splice acceptor site of exon 2 and all of exon 3 was replaced with a neomycin selection cassette. RT-PCR analysis on E12 peripheral blood of homozygous E12 embryos demonstrated that no detectable transcript was produced from this allele. (J:35594)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Epor Mutation: 26 strains or lines available

References

• Original: J:35594 Kieran MW, et al., Thrombopoietin rescues in vitro erythroid colony formation from mouse embryos lacking the erythropoietin receptor. Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):9126-31
• All: 21 reference(s)