Fcgr3^tm1Jsv
Targeted Allele Detail

Summary

• Symbol: Fcgr3^tm1Jsv
• Name: Fc receptor, IgG, low affinity III; targeted mutation 1, J Sjef Verbeek
• MGI ID: MGI:1861924
• Synonyms: FcgammaRIII^-, Fcgr3^tm1Sjv
• Gene: Fcgr3 Location: Chr1:170878743-170892504 bp, - strand Genetic Position: Chr1, 78.8 cM
• Alliance: Fcgr3^tm1Jsv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:35057
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A hygromycin selection cassette replaced a genomic fragment containing sequences encoding the ligand binding and part of the transmembrane domains. RT-PCR analysis on NK fractions of splenocytes derived from homozygous mice demonstrated that no detectable transcript was produced from this allele. Flow cytometry analysis on NK cells, B lymphocytes, macrophages and neutrophils confirmed that no detectable cell surface protein was encoded by this allele. (J:35057)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Fcgr3 Mutation: 28 strains or lines available

References

• Original: J:35057 Hazenbos WL, et al., Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity. 1996 Aug;5(2):181-8
• All: 123 reference(s)