Gad2^tm1Bae
Targeted Allele Detail

Summary

• Symbol: Gad2^tm1Bae
• Name: glutamic acid decarboxylase 2; targeted mutation 1, Steinunn Baekkeskov
• MGI ID: MGI:1861928
• Synonyms: GAD 65 (-), GAD65 -
• Gene: Gad2 Location: Chr2:22512262-22583889 bp, + strand Genetic Position: Chr2, 15.15 cM, cytoband A-B
• Alliance: Gad2^tm1Bae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44638
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 1, downstream of the translation initiation start site. Western blot analysis on brain extracts from homozygous mice confirmed that no detectable protein is expressed from this allele. (J:44638)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gad2 Mutation: 60 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Epilepsy (J:44638).

References

• Original: J:44638 Kash SF, et al., Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14060-5
• All: 13 reference(s)