H2-DMa^tm1Luc
Targeted Allele Detail

Summary

• Symbol: H2-DMa^tm1Luc
• Name: histocompatibility 2, class II, locus DMa; targeted mutation 1, Luc van Kaer
• MGI ID: MGI:1861933
• Synonyms: H2-DM-, H2-M-, H-2M-, H2-M⁰, H2-Malpha^-
• Gene: H2-DMa Location: Chr17:34338667-34358075 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-DMa^tm1Luc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31625
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 1.5 kb fragment of the gene, encompassing the first and most of the second exon. (J:31625)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any H2-DMa Mutation: 27 strains or lines available

References

• Original: J:31625 Martin WD, et al., H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection. Cell. 1996 Feb 23;84(4):543-50
• All: 45 reference(s)