Hgs^tm1Sor
Targeted Allele Detail

Summary

• Symbol: Hgs^tm1Sor
• Name: HGF-regulated tyrosine kinase substrate; targeted mutation 1, Philippe Soriano
• MGI ID: MGI:1861937
• Synonyms: Hrs^-
• Gene: Hgs Location: Chr11:120358461-120374805 bp, + strand Genetic Position: Chr11, 84.16 cM
• Alliance: Hgs^tm1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55580
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 2.1 kb segment of the gene, which included exons 2, 3, and 4, encompassing the amino terminal region of the protein. In addition, the insertion produced a frameshift of exons 1 and 5. (J:55580)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hgs Mutation: 40 strains or lines available

References

• Original: J:55580 Komada M, et al., Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Genes Dev. 1999 Jun 1;13(11):1475-85
• All: 2 reference(s)