Igh-J^tm1Cgn
Targeted Allele Detail

Summary

• Symbol: Igh-J^tm1Cgn
• Name: immunoglobulin heavy chain, joining region; targeted mutation 1, University of Cologne
• MGI ID: MGI:1861941
• Synonyms: Igh-JH^delta, JH-, JHT, Rr150-J^tm1Cgn
• Gene: Igh-J Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64285
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: Deletional recombination mediated by cre-loxP resulted in the loss of the exons encoding the joining region and the intron enhancer of the immunoglobulin heavy chain locus (IgH). (J:64285)

Tumor Data

List all tumor models in MMHCdb carrying Igh-J^tm1Cgn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Igh-J Mutation: 13 strains or lines available

References

• Original: J:64285 Gu H, et al., Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell. 1993 Jun 18;73(6):1155-64
• All: 82 reference(s)