Il2rg^tm1Cgn
Targeted Allele Detail

Summary

• Symbol: Il2rg^tm1Cgn
• Name: interleukin 2 receptor, gamma chain; targeted mutation 1, University of Cologne
• MGI ID: MGI:1861947
• Synonyms: cgamma-, gamma^-, gammac^-, gc^-, Il2rg^-, IL-2Rgamma^-, Il2rg^tm1Rsky
• Gene: Il2rg Location: ChrX:100307991-100311861 bp, - strand Genetic Position: ChrX, 43.9 cM
• Alliance: Il2rg^tm1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22521
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a neomycin resistance cassette flanked by lox P sites, followed by homologous recombination and cre-mediated deletion, resulted in the excision of exons 2 - 6 of the gene. These exons encode the extracellular and transmembrane domains of the protein. (J:22521)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Il2rg Mutation: 179 strains or lines available

References

• Original: J:22521 DiSanto JP, et al., Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):377-81
• All: 124 reference(s)