Il5^tm1Kopf
Targeted Allele Detail

Summary

• Symbol: Il5^tm1Kopf
• Name: interleukin 5; targeted mutation 1, Manfred A Kopf
• MGI ID: MGI:1861948
• Synonyms: IL-5-, IL-5^null
• Gene: Il5 Location: Chr11:53611621-53615930 bp, + strand Genetic Position: Chr11, 31.99 cM, cytoband A5/B1
• Alliance: Il5^tm1Kopf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30867
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A neomycin resistance cassette was inserted into exon 3 of the gene. (J:30867)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Il5 Mutation: 31 strains or lines available

References

• Original: J:30867 Kopf M, et al., IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity. 1996 Jan;4(1):15-24
• All: 76 reference(s)