Stat1^tm1Rds
Targeted Allele Detail

Summary

• Symbol: Stat1^tm1Rds
• Name: signal transducer and activator of transcription 1; targeted mutation 1, Robert D Schreiber
• MGI ID: MGI:1861949
• Synonyms: 129:Stat1-null, S1KO, STAT1^-
• Gene: Stat1 Location: Chr1:52158599-52201024 bp, + strand Genetic Position: Chr1, 26.81 cM
• Alliance: Stat1^tm1Rds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31326
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the first three coding exons and 0.7kb of 5' upstream flanking sequence. (J:31326)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Stat1^tm1Rds

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Stat1 Mutation: 74 strains or lines available

References

• Original: J:31326 Meraz MA, et al., Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell. 1996 Feb 9;84(3):431-42
• All: 237 reference(s)