Il4ra^tm1Sz
Targeted Allele Detail

Summary

• Symbol: Il4ra^tm1Sz
• Name: interleukin 4 receptor, alpha; targeted mutation 1, Leonard Shultz
• MGI ID: MGI:1861951
• Synonyms: IL-4R-, IL-4Ralpha-, Il-4ralpha^tm1Sz, Il4ra^tm1, IL-4R KO
• Gene: Il4ra Location: Chr7:125151443-125178646 bp, + strand Genetic Position: Chr7, 68.94 cM
• Alliance: Il4ra^tm1Sz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43656
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced exons 7 - 9 of the gene. (J:43656)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Il4ra Mutation: 46 strains or lines available

References

• Original: J:43656 Noben-Trauth N, et al., An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10838-43
• All: 168 reference(s)