Itgb7^tm1Cgn
Targeted Allele Detail

Summary

• Symbol: Itgb7^tm1Cgn
• Name: integrin beta 7; targeted mutation 1, University of Cologne
• MGI ID: MGI:1861953
• Synonyms: beta7^-, Itgb^tm1Ctg
• Gene: Itgb7 Location: Chr15:102124430-102140379 bp, - strand Genetic Position: Chr15, 57.39 cM
• Alliance: Itgb7^tm1Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34306
• Parent Cell Line: BL/6-III (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced part of exon 12 and all of exons 13 and 14, which encode the transmembrane and part of the extracellular domains. (J:34306)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Itgb7 Mutation: 72 strains or lines available

References

• Original: J:34306 Wagner N, et al., Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature. 1996 Jul 25;382(6589):366-70
• All: 55 reference(s)