Inpp5d^tm1Dmt
Targeted Allele Detail

Summary

• Symbol: Inpp5d^tm1Dmt
• Name: inositol polyphosphate-5-phosphatase D; targeted mutation 1, Dan Dumont
• MGI ID: MGI:1861956
• Synonyms: Ship -, SHIP-1^-, SHIP1^-
• Gene: Inpp5d Location: Chr1:87548034-87648229 bp, + strand Genetic Position: Chr1, 44.44 cM, cytoband C5
• Alliance: Inpp5d^tm1Dmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72477
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced all of exon 1 and part of intron 1. (J:72477)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Inpp5d Mutation: 94 strains or lines available

References

• Original: J:72477 Liu Q, et al., The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling. J Exp Med. 1998 Oct 5;188(7):1333-42
• All: 23 reference(s)