Lrp8^tm1Her
Targeted Allele Detail

Summary

• Symbol: Lrp8^tm1Her
• Name: low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 1, Joachim Herz
• MGI ID: MGI:1861964
• Synonyms: ApoER2-, Lp8^tm1Her
• Gene: Lrp8 Location: Chr4:107659337-107734037 bp, + strand Genetic Position: Chr4, 50.18 cM, cytoband C7
• Alliance: Lrp8^tm1Her page

Disruption of hippocampal layers in Lrp8^tm1Her/Lrp8^tm1Her, Pafah1b1^tm1Awb/Pafah1b1⁺, and Lrp8^tm1Her/Lrp8^tm1Her Pafah1b1^tm1Awb/Pafah1b1⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55691
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 17 and 18, which encode most of the membrane spanning segment and part of the cytoplasmic tail. (J:55691)

Expression

In Mice Carrying this Mutation:	15 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrp8 Mutation: 43 strains or lines available

References

• Original: J:55691 Trommsdorff M, et al., Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Cell. 1999 Jun 11;97(6):689-701
• All: 59 reference(s)