Mar1^tm1Wtg
Targeted Allele Detail

Summary

• Symbol: Mar1^tm1Wtg
• Name: matrix associated region 1; targeted mutation 1, William T Garrard
• MGI ID: MGI:1861975
• Synonyms: MAR-
• Gene: Mar1 Location: unknown Genetic Position: Chr6, Syntenic
• Alliance: Mar1^tm1Wtg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68024
• Parent Cell Line: KG-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A "hit and run" procedure was utilized to delete a 420 bp fragment of the gene, from nucleotide 3251 - 3670. (J:68024)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mar1 Mutation: 1 strain or line available

References

• Original: J:68024 Yi M, et al., Evidence that the Igkappa gene MAR regulates the probability of premature V-J joining and somatic hypermutation. J Immunol. 1999 May 15;162(10):6029-39
• All: 1 reference(s)