Nog^tm1Amc
Targeted Allele Detail

Summary

• Symbol: Nog^tm1Amc
• Name: noggin; targeted mutation 1, Andrew P McMahon
• MGI ID: MGI:1862000
• Synonyms: Nog^-, Nog^9E, noggin^-, Noggin^lacZ
• Gene: Nog Location: Chr11:89191464-89193158 bp, - strand Genetic Position: Chr11, 54.34 cM
• Alliance: Nog^tm1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47724
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Gene targeting generated a null allele by fusing the first 10 amino acids of coding sequence in-frame to the lacZ gene. The remainder of the coding sequence and some of the 3' flanking sequence of the gene were deleted. Ectopic expression of the resulting transcript was noted. (J:47724)

Disease models

Expression

In Mice Carrying this Mutation:	430 assay results
In Structures Affected by this Mutation:	47 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Nog Mutation: 18 strains or lines available

References

• Original: J:47724 McMahon JA, et al., Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 1998 May 15;12(10):1438-52
• All: 62 reference(s)