Zic2^Ku
Chemically induced Allele Detail

Summary

• Symbol: Zic2^Ku
• Name: zinc finger protein of the cerebellum 2; kumba
• MGI ID: MGI:1862004
• Synonyms: Gena29, GENA 29, Ku
• Gene: Zic2 Location: Chr14:122712847-122717264 bp, + strand Genetic Position: Chr14, 65.97 cM
• Alliance: Zic2^Ku page

Mutation origin

• Strain of Origin: BALB/cAnNCrl

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation in the kumba mouse was identified as a T to A transversion at coding nucleotide 1105. The resulting missense mutation (p.C369S), is located in the fourth zinc finger domain and the altered cysteine is a canonical residue required to to chelate zinc. Mutations in equivalent residues of other zinc finger proteins predict that this substitution would abolish the function of the zinc finger domain. (J:86841)
• Inheritance: Dominant

Disease models

Expression

In Mice Carrying this Mutation:	72 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Zic2 Mutation: 41 strains or lines available

References

• Original: J:63816 Nolan PM, et al., A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet. 2000 Aug;25(4):440-3
• All: 12 reference(s)