Aff1^Rob
Chemically induced Allele Detail

Summary

• Symbol: Aff1^Rob
• Name: AF4/FMR2 family, member 1; robotic
• MGI ID: MGI:1862020
• Synonyms: Gena180, GENA 180, Rob
• Gene: Aff1 Location: Chr5:103840307-104003188 bp, + strand Genetic Position: Chr5, 50.45 cM, cytoband E
• Alliance: Aff1^Rob page

Mutation origin

• Strain of Origin: BALB/cAnNCrl

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation in the robotic mouse was identified as a T to C transition in the second base of codon 280 resulting in a valine to alanine substitution (p.V280A) in a highly conserved region of the encoded protein. (J:82265)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Aff1 Mutation: 315 strains or lines available

References

• Original: J:63816 Nolan PM, et al., A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. Nat Genet. 2000 Aug;25(4):440-3
• All: 3 reference(s)