Lim2^To3
Chemically induced Allele Detail

Summary

• Symbol: Lim2^To3
• Name: lens intrinsic membrane protein 2; total opacity 3
• MGI ID: MGI:1862040
• Synonyms: ENU-288
• Gene: Lim2 Location: Chr7:43079523-43085420 bp, + strand Genetic Position: Chr7, 28.25 cM
• Alliance: Lim2^To3 page

Mutation origin

• Strain of Origin: (102/El x C3H/HeEl)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A G-to-T transversion in exon 2, the first coding exon, results in the non-conservative substitution of valine for glycine at amino acid position 15 of the protein. (J:46338)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lim2 Mutation: 15 strains or lines available

References

• Original: J:34877 Kerscher S, et al., Two new cataract loci, Ccw and To3, and further mapping of the Npp and Opj cataracts in the mouse. Genomics. 1996 Aug 15;36(1):17-21
• All: 5 reference(s)