Ntrk1^tm1Bbd
Targeted Allele Detail

Summary

• Symbol: Ntrk1^tm1Bbd
• Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1, Mariano Barbacid
• MGI ID: MGI:1888374
• Synonyms: trkA-, trkAK-, trk^TK
• Gene: Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
• Alliance: Ntrk1^tm1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17194
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences encoding 51 amino acids of the kinase catalytic domain were replaced with a neomycin cassette. RNase protection analysis on tissues isolated from homozygous mutant mice failed to identify any Ntrk1 transcripts. (J:17194)

Disease models

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntrk1 Mutation: 62 strains or lines available

References

• Original: J:17194 Smeyne RJ, et al., Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene [see comments]. Nature. 1994 Mar 17;368(6468):246-9
• All: 28 reference(s)