Ntrk1^tm1Bbd
Targeted Allele Detail

Summary

• Symbol: Ntrk1^tm1Bbd
• Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1, Mariano Barbacid
• MGI ID: MGI:1888374
• Synonyms: trkA-, trkAK-, trk^TK
• Gene: Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
• Alliance: Ntrk1^tm1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17194
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences encoding 51 amino acids of the kinase catalytic domain were replaced with a neomycin cassette. RNase protection analysis on tissues isolated from homozygous mutant mice failed to identify any Ntrk1 transcripts. (J:17194)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1  Disease Model	Ntrk1^tm1Bbd/Ntrk1^tm1Bbd	involves: 129S2/SvPas
hm2	Ntrk1^tm1Bbd/Ntrk1^tm1Bbd	involves: 129S2/SvPas * C57BL/6

Phenotypes:

Affected Systems	hm1	hm2
show or hide all annotated terms
behavior/neurological	√
unresponsive to tactile stimuli	√
abnormal vibrissae reflex	√
increased thermal nociceptive threshold	√
growth/size/body	√
decreased body size	√
hearing/vestibular/ear		N
hearing/vestibular/ear phenotype		N
integument	√
mottled coat	√
skin lesions	√
limbs/digits/tail	√
abnormal digit morphology	√
ulcerated autopod	√
mortality/aging	√
premature death	√
postnatal lethality, incomplete penetrance	√
nervous system	√
abnormal sympathetic ganglion morphology	√
small superior cervical ganglion	√
abnormal cholinergic neuron morphology	√
small trigeminal ganglion	√
small dorsal root ganglion	√
abnormal sympathetic nervous system physiology	√
pigmentation	√
mottled coat	√
vision/eye	√
miotic pupil	√
cornea opacity	√
blepharoptosis	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	hm1
hereditary sensory neuropathy IDs hereditary sensory neuropathy       DOID:0050548 MESH:D009477 OMIM:PS162400 Close	√

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntrk1 Mutation: 62 strains or lines available

References

• Original: J:17194 Smeyne RJ, et al., Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene [see comments]. Nature. 1994 Mar 17;368(6468):246-9
• All: 28 reference(s)