Ntrk3^tm1Bbd
Targeted Allele Detail

Summary

• Symbol: Ntrk3^tm1Bbd
• Name: neurotrophic tyrosine kinase, receptor, type 3; targeted mutation 1, Mariano Barbacid
• MGI ID: MGI:1888375
• Synonyms: trkC-, trkCK-, trkC^TK
• Gene: Ntrk3 Location: Chr7:77825711-78228865 bp, - strand Genetic Position: Chr7, 44.01 cM
• Alliance: Ntrk3^tm1Bbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:17195
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Insertion of a neomycin cassette into exon K2, which encodes part of the kinase domain of the protein. An alternatively spliced mRNA was detectable in an RNase protection analysis on tissues derived from homozygous mutant mice; these transcripts spliced from exon K1 to K3. A partial protein product is predicted to be expressed from this allele. (J:17195)

Expression

In Mice Carrying this Mutation:	7 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ntrk3^tm1Bbd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ntrk3 Mutation: 67 strains or lines available

References

• Original: J:17195 Klein R, et al., Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements [see comments]. Nature. 1994 Mar 17;368(6468):249-51
• All: 41 reference(s)