Prlr^tm1Cnp
Targeted Allele Detail

Summary

• Symbol: Prlr^tm1Cnp
• Name: prolactin receptor; targeted mutation 1, Paul A Kelly
• MGI ID: MGI:1888377
• Synonyms: Prlr-, PRLRko
• Gene: Prlr Location: Chr15:10177324-10349266 bp, + strand Genetic Position: Chr15, 5.23 cM
• Alliance: Prlr^tm1Cnp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:38093
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into exon 5, creating an in-frame stop codon. Northern, Western, and binding data all demonstrate the lack of a functional receptor in homozygous mutant animals. (J:38093)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Prlr^tm1Cnp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Prlr Mutation: 44 strains or lines available

References

• Original: J:38093 Ormandy CJ, et al., Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev. 1997 Jan 15;11(2):167-78
• All: 70 reference(s)