Sst^tm1Ute
Targeted Allele Detail

Summary

• Symbol: Sst^tm1Ute
• Name: somatostatin; targeted mutation 1, Ute Hochgeschwender
• MGI ID: MGI:1888381
• Synonyms: Srif-, Sst-, Sst KO
• Gene: Sst Location: Chr16:23708323-23709708 bp, - strand Genetic Position: Chr16, 15.0 cM, cytoband cen-C3
• Alliance: Sst^tm1Ute page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70426
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An SV40-tk-neo cassette was inserted, thereby deleting the last 30 bp of exon 1 and the first 39 basepairs of inton 1. Successful recombination was shown by Southern blot. Northern blot indicated lack of transcript and radioimmunoassay demonstrated the lack of protein from homozygous mutants. (J:70426)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Sst Mutation: 37 strains or lines available

References

• Original: J:70426 Zeyda T, et al., Impairment in motor learning of somatostatin null mutant mice. Brain Res. 2001 Jul 6;906(1-2):107-14
• All: 12 reference(s)