Snca^tm1Rosl
Targeted Allele Detail

Summary

• Symbol: Snca^tm1Rosl
• Name: synuclein, alpha; targeted mutation 1, Arnon Rosenthal
• MGI ID: MGI:1888382
• Synonyms: alpha-Syn^-, alpha-Synko
• Gene: Snca Location: Chr6:60708559-60806839 bp, - strand Genetic Position: Chr6, 29.15 cM
• Alliance: Snca^tm1Rosl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60151
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette was used to delete exons 1 and 2, encoding amino acids 1 through 41 as well as a 5' untranslated region. RT-PCR analysis of extracts from the brains of homozygous mutant mice, using probes for both the deleted 5' region as well the untargeted 3' region, showed an absence of transcript. Western blot analysis, immunohistochemical analysis, and in situ hybridization confirmed a lack of encoded protein in homozygous mutant mice. (J:60151)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Snca Mutation: 36 strains or lines available

References

• Original: J:60151 Abeliovich A, et al., Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron. 2000 Jan;25(1):239-52
• All: 105 reference(s)