Sparc^tm1Hwe
Targeted Allele Detail

Summary

• Symbol: Sparc^tm1Hwe
• Name: secreted acidic cysteine rich glycoprotein; targeted mutation 1, Chin Chen Howe
• MGI ID: MGI:1888383
• Synonyms: SP^-
• Gene: Sparc Location: Chr11:55284985-55310906 bp, - strand Genetic Position: Chr11, 33.04 cM, cytoband B1
• Alliance: Sparc^tm1Hwe page

Delayed wound healing in Sparc^tm1Hwe/Sparc^tm1Hwe mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52120
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Two tandem neomycin resistance cassettes were inserted into exon 4. No mRNA was detected by Northern blot in testis, spleen or thymus of homozygous mice. (J:52120)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Sparc^tm1Hwe

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Sparc Mutation: 76 strains or lines available

References

• Original: J:52120 Norose K, et al., SPARC deficiency leads to early-onset cataractogenesis. Invest Ophthalmol Vis Sci. 1998 Dec;39(13):2674-80
• All: 92 reference(s)