Scarb1^tm1Kri
Targeted Allele Detail

Summary

• Symbol: Scarb1^tm1Kri
• Name: scavenger receptor class B, member 1; targeted mutation 1, Monty Krieger
• MGI ID: MGI:1888384
• Synonyms: srb1-, Sr-b1^-, srbI^-, SR-BI, SR-BI^-, SR-BI KO
• Gene: Scarb1 Location: Chr5:125354151-125418082 bp, - strand Genetic Position: Chr5, 64.11 cM
• Alliance: Scarb1^tm1Kri page

Apoe^tm1Unc/Apoe^tm1Unc Scarb1^tm1Kri/Scarb1^tm1Kri mice develop occlusive, atherosclerotic coronary artery disease

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44187
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of the entire coding region of the first exon and an additional 554 bases of intron 1 with a neomycin cassette. (J:44187)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Scarb1 Mutation: 53 strains or lines available

References

• Original: J:44187 Rigotti A, et al., A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12610-5
• All: 131 reference(s)