Stat6^tm1Gru
Targeted Allele Detail

Summary

• Symbol: Stat6^tm1Gru
• Name: signal transducer and activator of transcription 6; targeted mutation 1, Michael J Grusby
• MGI ID: MGI:1888385
• Synonyms: S6KO, Stat6^-
• Gene: Stat6 Location: Chr10:127478855-127496826 bp, + strand Genetic Position: Chr10, 74.59 cM
• Alliance: Stat6^tm1Gru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31932
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region encoding the SH2 domain, which is essential for dimerization, was replaced by the insertion of a neomycin selection cassette. Immunoblot analysis of lysates from the spleens and thymi of homozygous mutant mice showed an absence of encoded protein. (J:31932)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Stat6 Mutation: 53 strains or lines available

References

• Original: J:31932 Kaplan MH, et al., Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity. 1996 Mar;4(3):313-9
• All: 386 reference(s)