Tfap2a^tm1Jae
Targeted Allele Detail

Summary

• Symbol: Tfap2a^tm1Jae
• Name: transcription factor AP-2, alpha; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:1888387
• Synonyms: AP-2 -
• Gene: Tfap2a Location: Chr13:40868778-40891852 bp, - strand Genetic Position: Chr13, 20.01 cM, cytoband A5-B1
• Alliance: Tfap2a^tm1Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33032
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 5, which encodes part of the DNA binding domain of the protein. (J:33032)

Expression

In Mice Carrying this Mutation:	110 assay results
In Structures Affected by this Mutation:	22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tfap2a Mutation: 39 strains or lines available

References

• Original: J:33032 Schorle H, et al., Transcription factor AP-2 essential for cranial closure and craniofacial development. Nature. 1996 May 16;381(6579):235-8
• All: 7 reference(s)