Tgfb2^tm1Doe
Targeted Allele Detail

Summary

• Symbol: Tgfb2^tm1Doe
• Name: transforming growth factor, beta 2; targeted mutation 1, Thomas Doetschman
• MGI ID: MGI:1888389
• Synonyms: TGBbeta2-, Tgfb2^-, TGF-beta2-
• Gene: Tgfb2 Location: Chr1:186354989-186438186 bp, - strand Genetic Position: Chr1, 89.95 cM
• Alliance: Tgfb2^tm1Doe page

Thin cornea and iridocorneal dysgenesis in Ext1^tm1Yama/Ext1⁺ H2az2^{Tg(Wnt1-cre)11Rth}/0 Tgfb2^tm1Doe/Tgfb2⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41682
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 6 was disrupted by the insertion of a neomycin selection cassette. The insertion introduced stop codons in all three reading frames. RT-PCR analysis showed an absence of normal message in homozygous mutant mice. (J:41682)

Disease models

Expression

In Mice Carrying this Mutation:	209 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	70 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tgfb2 Mutation: 36 strains or lines available

Notes

Homozygotes exhibit a "Peters'-like" anomaly instead of an Axenfeld-Reiger's and Peter's anomaly (J:73681).

References

• Original: J:41682 Sanford LP, et al., TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development. 1997 Jul;124(13):2659-70
• All: 51 reference(s)