Ndst1^tm1Ekf
Targeted Allele Detail

Summary

• Symbol: Ndst1^tm1Ekf
• Name: N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1; targeted mutation 1, Erik Forsberg
• MGI ID: MGI:1888706
• Synonyms: NDST-1^-
• Gene: Ndst1 Location: Chr18:60817566-60881722 bp, - strand Genetic Position: Chr18, 34.38 cM, cytoband D2
• Alliance: Ndst1^tm1Ekf page

Newborn Ndst1^tm1Ekf/Ndst1^tm1Ekf mice display lung atelectasia

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63996
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The functional mutant was generated by replacing the 3' portion of exon 1, which included the first 171 amino acids comprising both the cytoplasmic and trans-Golgi membrance domains, with a PGK-neo cassette. (J:63996)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndst1 Mutation: 47 strains or lines available

References

• Original: J:63996 Ringvall M, et al., Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1. J Biol Chem. 2000 Aug 25;275(34):25926-30
• All: 4 reference(s)