Timp2^tm1Pds
Targeted Allele Detail

Summary

• Symbol: Timp2^tm1Pds
• Name: tissue inhibitor of metalloproteinase 2; targeted mutation 1, Paul D Soloway
• MGI ID: MGI:1888708
• Synonyms: Timp2-, TIMP-2KO, TIMP2KO
• Gene: Timp2 Location: Chr11:118191887-118246237 bp, - strand Genetic Position: Chr11, 83.09 cM
• Alliance: Timp2^tm1Pds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64001
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of the first coding exon with a neomycin cassette. (J:64001)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

22 assay results 2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Timp2 Mutation: 22 strains or lines available

References

• Original: J:64001 Wang Z, et al., TIMP-2 is required for efficient activation of proMMP-2 in vivo. J Biol Chem. 2000 Aug 25;275(34):26411-5
• All: 26 reference(s)