Timp2^tm1Jjc
Targeted Allele Detail

Summary

• Symbol: Timp2^tm1Jjc
• Name: tissue inhibitor of metalloproteinase 2; targeted mutation 1, John J Caterina
• MGI ID: MGI:1888709
• Synonyms: Timp-2^-
• Gene: Timp2 Location: Chr11:118191887-118246237 bp, - strand Genetic Position: Chr11, 83.09 cM
• Alliance: Timp2^tm1Jjc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64002
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of exons 2 and 3 with a neomycin cassette. (J:64002)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Timp2 Mutation: 22 strains or lines available

References

• Original: J:64002 Caterina JJ, et al., Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activation. J Biol Chem. 2000 Aug 25;275(34):26416-22
• All: 3 reference(s)