Ext1^tm1Dews
Targeted Allele Detail

Summary

• Symbol: Ext1^tm1Dews
• Name: exostosin glycosyltransferase 1; targeted mutation 1, Dan E Wells
• MGI ID: MGI:1888710
• Synonyms: EXT1-
• Gene: Ext1 Location: Chr15:52931657-53209579 bp, - strand Genetic Position: Chr15, 20.0 cM
• Alliance: Ext1^tm1Dews page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64021
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.3 kb genomic fragment containing part of exon 1 and intron 1 was replaced by a promoterless lacZ gene that was fused in frame with the exon 1 sequences. (J:64021)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ext1 Mutation: 65 strains or lines available

References

• Original: J:64021 Lin X, et al., Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice. Dev Biol. 2000 Aug 15;224(2):299-311
• All: 7 reference(s)