Htr2b^tm1Lum
Targeted Allele Detail

Summary

• Symbol: Htr2b^tm1Lum
• Name: 5-hydroxytryptamine (serotonin) receptor 2B; targeted mutation 1, Luc Maroteaux
• MGI ID: MGI:1888735
• Synonyms: 5-HT2B-, 5-HT2BR^-
• Gene: Htr2b Location: Chr1:86026748-86039692 bp, - strand Genetic Position: Chr1, 43.94 cM
• Alliance: Htr2b^tm1Lum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64067
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of exon 2 with a neomycin resistance gene. (J:64067)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Htr2b Mutation: 28 strains or lines available

References

• Original: J:64067 Nebigil CG, et al., Serotonin 2B receptor is required for heart development. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9508-13
• All: 27 reference(s)