Cdkn1b^tm1Kin
Targeted Allele Detail

Summary

• Symbol: Cdkn1b^tm1Kin
• Name: cyclin dependent kinase inhibitor 1B; targeted mutation 1, Kei-ichi Nakayama
• MGI ID: MGI:1888790
• Synonyms: p27^-, p27^Kip1-, p27^Kip1
• Gene: Cdkn1b Location: Chr6:134897364-134902476 bp, + strand Genetic Position: Chr6, 65.77 cM
• Alliance: Cdkn1b^tm1Kin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33402
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette in reverse orientation replaced a 2.5kb sequence containing exons 1 and 2. This deletes the entire coding portion of the gene. Immunoblots of whole tissue lysates of the thymus demnonstrate the absence of protein product. (J:33402)

Expression

In Mice Carrying this Mutation:	44 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn1b^tm1Kin

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn1b Mutation: 26 strains or lines available

References

• Original: J:33402 Nakayama K, et al., Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell. 1996 May 31;85(5):707-20
• All: 31 reference(s)